Treatment for glioblastoma (GBM)
Intended for US audiences only.
Optune® Novocure™

Optune®: Study in recurrent GBM

For people with recurrent GBM, a large clinical study has shown that Optune is as effective as chemotherapy, with patients self-reporting better quality of life.


Optune is as effective as chemotherapy in a clinical trial

In a large clinical trial of patients with recurrent GBM, Optune was shown to be as effective as chemotherapy. Patients using Optune and those receiving chemotherapy lived for a median* of about 6 months.

Median survival on chemotherapy was 6 months. Median survival on Optune® was 6.6 months.

*The median was the point where half of the patients in a group were still alive.

Quality of life

Compared to people who took chemotherapy, people who used Optune in a clinical trial self-reported better quality of life, with improved cognitive and emotional functioning.

Side effects

The most common (≥10%) side effects that people with recurrent GBM reported while using Optune alone in a clinical trial were scalp irritation from device use and headache. Optune was not shown to cause many of the most common (≥10%) side effects of chemotherapy.

The following adverse reactions were considered related to Optune when using the device alone: scalp irritation from device use, headache, malaise, muscle twitching, fall and skin ulcer.

Optune® side effects are scalp irritation and headache. Chemotherapy side effects are headache, malaise, low blood platelet count, nausea, and diarrhea.

Before you start therapy with Optune, you'll want to consider some of the potential benefits and side effects. For people with recurrent GBM, Optune is used alone. Some of the benefits of Optune may vary based on where you are in your diagnosis and treatment plan.


The benefits of Optune® are that compared with people who took chemotherapy, people who used Optune reported a better quality of life, it treats where the tumor is, and it is a portable therapy. The most common side effects that people reported while using Optune alone were scalp irritation from device use and headache.

Please click here to see the Optune Instructions For Use (IFU) for complete information regarding the device's indications, contraindications, warnings, and precautions.

1. Optune Instructions For Use. Novocure 2016.
2. Stupp R, Wong ET, Kanner AA, et al. NovoTTF-100A versus physician’s choice chemotherapy in recurrent glioblastoma: a randomised phase III trial of a novel treatment modality. Eur J Cancer. 2012;48(14):2192-2202.

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What is Optune® approved to treat?

Optune is a wearable, portable, FDA-approved device indicated to treat a type of brain cancer called glioblastoma multiforme (GBM) in adult patients 22 years of age or older.

Newly diagnosed GBM

If you have newly diagnosed GBM, Optune is used together with a chemotherapy called temozolomide (TMZ) if:

Recurrent GBM

If your tumor has come back, Optune can be used alone as an alternative to standard medical therapy if:

Who should not use Optune?

Optune is not for everyone. Talk to your doctor if you have:

Do not use Optune if you are pregnant or are planning to become pregnant. It is not known if Optune is safe or effective during pregnancy.

What should I know before using Optune?

Optune should only be used after receiving training from qualified personnel, such as your doctor, a nurse, or other medical staff who have completed a training course given by Novocure™, the maker of Optune.

What are the possible side effects of Optune?

Most common side effects of Optune when used together with chemotherapy (temozolomide, or TMZ) were low blood platelet count, nausea, constipation, vomiting, tiredness, scalp irritation from the device, headache, seizure, and depression.

The most common side effects when using Optune alone were scalp irritation (redness and itchiness) and headache. Other side effects were malaise, muscle twitching, fall and skin ulcers.

Talk to your doctor if you have any of these side effects or questions.


Please click here to see the Optune Instructions For Use (IFU) for complete information regarding the device's indications, contraindications, warnings, and precautions.

Indications For Use

Optune is intended as a treatment for adult patients (22 years of age or older) with histologically-confirmed glioblastoma multiforme (GBM).