Treatment for glioblastoma (GBM)
Intended for US audiences only.
Optune® Novocure™

Optune®: Study in newly diagnosed GBM

For people with newly diagnosed GBM, living longer may be possible when Optune is used together with the chemotherapy temozolomide (TMZ). In a clinical trial, using Optune with TMZ was shown to delay GBM tumor growth and extend survival compared with TMZ alone. If you have newly diagnosed GBM and you and your doctor decide to start Optune, it would be used together with the chemotherapy temozolomide (TMZ), after you have already had surgery and radiation with TMZ.


Optune® and TMZ combined is more effective than TMZ alone in a clinical trial


In a clinical study, people with newly diagnosed GBM who used Optune and TMZ had a median* of 7.2 months without their tumor progressing (growing). In comparison, people who used TMZ alone had a median of 4 months without their tumor progressing.


Combining Optune® and TMZ resulted in a median of 3.2 additional months than TMZ alone

*The median was the point where half of the patients in a group had not shown evidence of their tumor progressing.

In the same study, people with newly diagnosed GBM who used Optune and TMZ lived for a median of 20.5 months. In comparison, people who used TMZ alone lived for a median of 15.6 months.


Combining Optune® and TMZ resulted in a median of 4.9 additional months than TMZ alone

The median was the point where half of the patients in a group were still alive.

Approximately half of the people who used Optune with TMZ were alive at 2 years or longer, compared to 32% who were on TMZ alone.


48% of patients lived 2 years or longer when combining Optune® with TMZ


In a long-term follow-up of 695 people in the same study, the median survival and median progression-free survival§ were consistent. Survival at 5 years was 13% for Optune + TMZ vs 5% for TMZ alone.

The median was the point where half of the patients in a group were still alive.
§The median was the point where half of the patients in a group had not shown evidence of their tumor progressing.


Optune + TMZ significantly improved median progression-free survival


Before you start therapy, you'll want to learn more about the other benefits and side effects of using Optune.


The benefits of Optune® are it is used with the chemotherapy temozolomide, it treats where the tumor is and thus did not significantly increase TMZ-related side effects, and it is a portable therapy. The most common side effects of Optune® + TMZ that people reported while using Optune with TMZ were low blood platelet count, nausea, constipation, vomiting, fatigue, scalp irritation from device use, headache, convulsions, and depression



Please click here to see the Optune Instructions For Use (IFU) for complete information regarding the device's indications, contraindications, warnings, and precautions.

1. Optune Instructions For Use. Novocure 2016.
2. Stupp R, Hegi ME, Idbaih A, et al. Tumor treating fields added to standard chemotherapy in newly diagnosed glioblastoma (GBM): final results of a randomized, multicenter, phase III trial. In: Program and abstracts of the 2017 Annual Meeting of the American Association for Cancer Research; April 1-5, 2017; Washington, DC. Abstract LBA AACR CT007.

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What is Optune® approved to treat?

Optune is a wearable, portable, FDA-approved device indicated to treat a type of brain cancer called glioblastoma multiforme (GBM) in adult patients 22 years of age or older.

Newly diagnosed GBM

If you have newly diagnosed GBM, Optune is used together with a chemotherapy called temozolomide (TMZ) if:

Recurrent GBM

If your tumor has come back, Optune can be used alone as an alternative to standard medical therapy if:

Who should not use Optune?

Optune is not for everyone. Talk to your doctor if you have:

Do not use Optune if you are pregnant or are planning to become pregnant. It is not known if Optune is safe or effective during pregnancy.

What should I know before using Optune?

Optune should only be used after receiving training from qualified personnel, such as your doctor, a nurse, or other medical staff who have completed a training course given by Novocure™, the maker of Optune.

What are the possible side effects of Optune?

Most common side effects of Optune when used together with chemotherapy (temozolomide, or TMZ) were low blood platelet count, nausea, constipation, vomiting, tiredness, scalp irritation from the device, headache, seizure, and depression.

The most common side effects when using Optune alone were scalp irritation (redness and itchiness) and headache. Other side effects were malaise, muscle twitching, fall and skin ulcers.

Talk to your doctor if you have any of these side effects or questions.


Please click here to see the Optune Instructions For Use (IFU) for complete information regarding the device's indications, contraindications, warnings, and precautions.

Indications For Use

Optune is intended as a treatment for adult patients (22 years of age or older) with histologically-confirmed glioblastoma multiforme (GBM).