Treatment for glioblastoma (GBM)
Intended for US audiences only.

Disease overview

What is the difference between newly diagnosed GBM and recurrent GBM?

When a GBM tumor is first confirmed by your doctor, it’s called newly diagnosed GBM. Even after 1 or 2 years, if your tumor has not come back as visible on your MRI results, it's still called newly diagnosed GBM.

Recurrent GBM is when GBM has come back after a period of time and GBM tumors are visible on your MRI.

Why GBM may return

Surgery, radiation, and/or chemotherapy may have removed or destroyed most GBM tumor cells. But, because of the location of the tumor and the "finger-like tentacles" of a GBM tumor that may spread across the brain, it may be difficult to reach all GBM cells. Some cancerous cells may remain and continue to grow.

A neurosurgeon explains how glioblastoma, tumor cells can be found far from where the tumor is seen on an MRI.

A neurosurgeon explains

“In glioblastoma, tumor cells can be found far from where the tumor is seen on an MRI. So, I set expectations from the very first conversation that, even when the postoperative MRI looks perfect, there are tumor cells left behind that will come back unless treated.”

—Steven Toms, MD, MPH, FACS, FAANS

References:
  1. Optune [Instructions for Use]. Novocure 2016.
  2. American Brain Tumor Association. Glioblastoma. https://www.abta.org/tumor_types/glioblastoma-gbm/. Accessed May 30, 2018.

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What is Optune approved to treat?

Optune is indicated to treat a type of brain cancer called glioblastoma multiforme (GBM) in adult patients 22 years of age or older.

Newly diagnosed GBM

If you have newly diagnosed GBM, Optune is used together with a chemotherapy called temozolomide (TMZ) if:

Recurrent GBM

If your tumor has come back, Optune can be used alone as an alternative to standard medical therapy if:

What is the NovoTTF-100L System approved to treat?

The NovoTTF-100L System is a wearable, portable, FDA-approved device indicated for the treatment of adult patients, with unresectable, locally advanced or metastatic, malignant pleural mesothelioma (MPM) to be used together with standard chemotherapy (pemetrexed and platinum-based chemotherapy).

Who should not use Optune for GBM or the NovoTTF-100L System for MPM?

Optune for GBM and the NovoTTF-100L System for MPM are not for everyone. Talk to your doctor if you have:

Do not use Optune for GBM or the NovoTTF-100L System for MPM if you are pregnant or are planning to become pregnant. It is not known if Optune/the NovoTTF-100L System is safe or effective during pregnancy.

What should I know before using Optune for GBM or the NovoTTF-100L System for MPM?

Optune and the NovoTTF-100L System should only be used after receiving training from qualified personnel, such as your doctor, a nurse, or other medical staff who have completed a training course given by Novocure®, the maker of Optune and the NovoTTF-100L System.

What are the possible side effects of Optune for GBM and the NovoTTF-100L System for MPM?

The most common side effects of Optune when used together with chemotherapy for GBM (temozolomide or TMZ) were low blood platelet count, nausea, constipation, vomiting, tiredness, scalp irritation from the device, headache, seizure, and depression.

The most common side effects when using Optune alone for GBM were scalp irritation (redness and itchiness) and headache. Other side effects were malaise, muscle twitching, fall and skin ulcers.

The most common side effects of the NovoTTF-100L System when used together with chemotherapy for MPM (pemetrexed and platinum-based chemotherapy) were low blood platelet count, constipation, nausea, tiredness, chest pain, fatigue, skin irritation from device use, itchy skin, and cough.

Other potential adverse effects associated with the use of the NovoTTF-100L System include: treatment related skin irritation, allergic reaction to the plaster or to the gel, electrode overheating leading to pain and/or local skin burns, infections at sites of electrode contact with the skin, local warmth and tingling sensation beneath the electrodes, muscle twitching, medical site reaction and skin breakdown/skin ulcer.

Talk to your doctor if you have any of these side effects or questions.

Caution: Federal law restricts the NovoTTF-100L System to sale by or on the order of a physician. Humanitarian Device. Authorized by Federal Law for use in the treatment of adult patients with unresectable, locally advanced or metastatic, malignant pleural mesothelioma concurrently with pemetrexed and platinum-based chemotherapy. The effectiveness of this device for this use has not been demonstrated.


Please click here to see the Optune Instructions for Use (IFU) for complete information regarding the device's indications, contraindications, warnings, and precautions.

Please click here to see the NovoTTF-100L IFU for complete information regarding the device's indications, contraindications, warnings, and precautions.


On this site, patient and healthcare professional videos as well as all images labeled as Optune users, caregivers, or healthcare professionals depict actual patients, caregivers, and healthcare professionals. All other depictions of patients and caregivers are actor portrayals. Patient images reflect the health status of the patients at the time each photo was taken.

What is Optune approved to treat?

Optune is indicated to treat a type of brain cancer called glioblastoma multiforme (GBM) in adult patients 22 years of age or older.